Ion-exchange Media
Ion-exchange (IEX) chromatography media is popularly employed to separate molecules, such as large proteins, small nucleotides and amino acids etc, based on their charge. The functional groups in IEX media have charges that bind molecules with opposite charges. Release of the bound molecules from the medium is achieved by displacement, via the application of an increasing concentration of a similarly charged molecule.
By design of the bead size, pore size, functional groups and the mechanical strength of individual base matrices, our IEX media can be used for capture of bulk product or impurities from large-volumes, as an intermediate purification step, or as a final step for high resolution purifications.
We offer an extensive range of ion exchange chromatography media (resins) in lab packs, bulk quantities and prepacked columns. Depending on the nature of your application, the property of your feedstock and the resolution you need, the general selection guide is shown along the product list below.
| IEX Product | Suitable Use |
| Q, DEAE, SP & CMSepFastTM 6HF(50-150 µm) | General purpose preparative grade IEX media Comparable to IEX Sepharose Fast FlowInexpensive |
| Q, DEAE, SP & CMSepFastTM 6HF Plus(50-150 µm) | Similar to IEX Sepharose FF XL, made of agarose and dextranIncreased binding capacity |
| Q, DEAE, SP & CMSepFastTM Large Beads(150-350 µm) | General purpose preparative grade IEX media Comparable to IEX Sepharose Big BeadsParticularly suitable for processing viscous or cell-containing feedstocks |
| Q, DEAE, SP & CMSepFastTM Large Beads Plus(150-350 µm) | Large beads made of agarose and dextranIncreased binding capacity at faster flowrates |
| Q, DEAE, SP & CMSepFastTM HighRes(20-50 µm) | Standard IEX media with reduced bead size to achieve better resolutionInexpensive |
| Q, DEAE, SP & CMSepFastTM HighRes Plus(20-50 µm) | Increased binding capacityIncreased resolution |
| SepFastTM Supor Q, DEAE, S, CM | Polishing of antibodiesPurification of viruses, VLPs and plasmids etc High capacity at high flow velocity |
| Magnetic SepFastTM Supor Q, DEAE, S, CM | High-throughput screening of phage library for drug discovery High-throughput purification of viruses |
| SepFastTM Macro (Q, S) | Purification of macro-molecules such as pegylated antibodiesHigh binding capacity and high resolution |
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