SepFastTM Macro IEX Media

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Introduction


Specially designed for the purification of large and complex protein molecules such as pegylated drug materials, SepFast Macro Q and SepFast Macro S is a group of strong anion exchange and strong cation exchange chromatography media, respectively.

The base matrix is made of highly cross-linked polysaccharides. It is very stable to most of the chemical conditions experienced in the bioprocessing industry. We provide the regulatory support files of individual resins for those cGMP applications.

The core advantages to large-scale biomanufacturing are:

  • Improved binding capacity
  • Good pressure / flow property
  • High Resolution

Characteristics of SepFast Macro products

 
SepFast Macro Q SepFast Macro S
Matrix Highly cross-linked polysaccharides
Functional
group		 Quaternary ammonium
strong anion		 Sulfo strong cation
Total ionic capacity 0.08-0.16 mmol/ml 0.08-0.16 mmol/ml
Particle size 20 – 50 μm
Pressure-flow property* >100 cm/h 
Operational pressure Up to 6 bar
pH stability 2-14 (short term) and 3-12 (long term)
Working temperature 4oC – 30oC
Chemical
stability		 All commonly used buffers; 1 M acetic acid, 1 M NaOH, 6M guanidine hydrochloride, 8 M urea, 30% isopropanol, 70% ethanol
Total ionic capacity Oxidizing agents, anionic detergents or cationic detergents
Storage 20% ethanol 20% ethanol + 0.2 M sodium acetate

*Measured in a 32 mm ID column at a bed height of 15 cm.

Ordering information

Ordering information
Description Quantity Code no. Price GBP
SepFast Macro Q 25 ml 460101 £93.71
  100 ml 460102 £326.34
  1 Litre 460103 POR
SepFast Macro S 25 ml 460201 £93.71
  100 ml 460202 £326.34
  1 Litre 460203 POR

*Pre-packed process development columns are available on request..

How to order

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